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What is histamine?

Most of us think of histamine as the immune chemical associated with allergy, but it has lots of other important functions in the body too, including communicating with the brain, triggering the release of stomach acid, and dilating blood vessels to lower blood pressure.

Discover our full range of health benefit guides and read more about popular diets. Looking for some more allergy advice? Check out our 10 foods to support your seasonal allergies and 10 natural approaches to help you through allergy season.

Why is histamine important?

We all need histamine, especially when we graze a knee or suffer a bee sting. That’s because histamine initiates the immune response that helps deal with injuries and fight infection.

Histamine is found throughout the body, but is mainly stored in special immune cells, called mast cells and basophils. It performs its role by attaching to receptors at key sites throughout the body.

When is histamine a problem?

Histamine can be a problem when levels get too high or we can’t break it down properly, at this point it can start to affect our normal bodily functions. This may lead to allergy-like symptoms, including itching, sneezing, headaches, joint pain, irritable bowel and nausea. You may not experience all of these symptoms all of the time, but as histamine accumulates its likely you’ll find your symptoms worsen.

Sadly, the condition which is often referred to as 'histamine intolerance' has a number of underlying mechanisms, and there is no reliable test to confirm a diagnosis.

Which health conditions are associated with excess histamine?

There are a number of conditions associated with high histamine – for example high levels may cause or worsen headaches and brain fog, lead to anxiety, insomnia, hives, bloating and nasal congestion, as well as worsen menstrual symptoms including pre-menstrual syndrome and period pain.

Interestingly, studies suggest histamine intolerance may be more common in women, especially those at mid-life. This is because histamine levels are likely to increase at ovulation or just before your period, when levels are influenced by fluctuating hormones, most notably levels of oestrogen.

What is a histamine ‘bucket’?

Histamine intolerance is unlike other allergies or sensitivities, because it is not a reaction to the histamine itself but to the fact that we’ve too much of it. This makes recognising and managing the condition very difficult. Whether you experience symptoms or not will also depend on whether your personal tolerance to the amount of histamine in your body has been breached. Often referred to as your histamine ‘bucket’, once this capacity is met and exceeded, your bucket starts to overflow and symptoms become more challenging.

There are numerous factors that influence how full your histamine ‘bucket’ might be. These include your genes, certain medication you might be taking, your diet, the time of year, nutritional deficiencies, stress levels, your hormones, gut health and the environment, including whether you suffer from environmental allergies like pollen, dust mites etc.

Understanding the limits of your own histamine ‘bucket’ is important and explains why on one day you may be able to enjoy a bowl of strawberries with your breakfast and on another it triggers symptoms.

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How will I know if a histamine intolerance is relevant to me?

One of the most useful tools in assessing whether your symptoms are that of histamine intolerance is to follow a low-histamine diet. This should not be considered a long-term treatment option, because following any restrictive diet is unlikely to be nutritionally appropriate for the longer term.

Ideally, work with a registered dietician to minimise foods that are high in histamine or histamine-releasing. Using a food diary, record your reaction to foods as you slowly reintroduce them, while carefully assessing your tolerance levels and considering other relevant factors. Over time and guided by your dietician, you’ll be able to establish a long-term eating plan that is balanced and appropriate for your needs.

Keeping a food diary helps identify problem foods and pinpoint preparation and cooking methods that may need to be adapted. It can be quite revealing and may even suggest some foods, such as those considered healthy, may be adding to your histamine load.

To help get you started, here are some common foods and their likely histamine effects. You should be aware that histamine levels may vary, so this is given for guidance only:

Read more about high-histamine foods and our top 20 low-histamine foods.

How can I manage my histamine levels?

In the first instance, eliminating alcohol, dairy and fermented foods may be helpful, because these foods are typically high in histamine and some promote the release of histamine. Other foods block the activity of the enzyme involved in breaking down histamine, so these should also be avoided or minimised, including caffeinated drinks.

A lot of sufferers turn to antihistamine medication to block histamine activity and relieve their symptoms, but it’s worth highlighting that these drugs don’t actually reduce your histamine load although you may benefit from symptom relief.

An alternative product is zeolite powder. This natural clay-like material is made up of minerals with a honeycomb structure that selectively absorbs and binds compounds, including histamine. By binding histamine in the gut and eliminating it via the stool, zeolite helps alleviate symptoms as well as lower levels in the body.

While there are many zeolite powders available, experts suggest using natural clinoptilolite zeolite, as it has been the most thoroughly researched in this area.

There are also some nutrients and plant compounds that act as natural antihistamines, and so inhibit the build-up of histamine. These include vitamins C and D, quercetin, bromelain and curcumin. Some people find including foods rich in these nutrients helps. Certain other nutrients support the activity of the diamine oxidase (DAO) enzyme, that’s the enzyme which breaks down histamine, these include the B vitamins, such as B6, and minerals including copper, zinc and manganese.

Read more about natural approaches to managing histamine levels.

What can I do today?

Here are some practical steps you can put in place straight away:

  • Buy and cook from fresh, shopping little and often - the fresher your food, the less histamine it is likely to contain. Cook from fresh whenever possible, rather than using leftovers or prepared foods. Freeze leftovers for use another day rather than storing them in the fridge.
  • Look at your lifestyle – for example, if environmental allergens are relevant for you, minimise your exposure.
  • Aim to manage stress levels, and explore which forms and levels of exercise are beneficial for you, because this can vary.
  • If you're experiencing a hormonal shift, for example puberty or peri-menopause, and are experiencing symptoms suggestive of a histamine intolerance, refer to your GP for guidance.

If you are considering attempting any form of change to your normal eating plan, please consult your GP first to ensure you can do so without risk to health.

Enjoyed this? Now read...

Do you have a food intolerance?
10 foods to support your seasonal allergies
10 natural approaches to help you through allergy season
A guide to high-histamine foods
Top 20 low-histamine foods

What are your experiences of histamine intolerance and how do you manage your symptoms? Comment below….


This article was reviewed on 17 June 2022 by Kerry Torrens.

Kerry Torrens BSc. (Hons) PgCert MBANT is a Registered Nutritionist with a post graduate diploma in Personalised Nutrition & Nutritional Therapy. She is a member of the British Association for Nutrition and Lifestyle Medicine (BANT) and a member of the Guild of Food Writers. Over the last 15 years she has been a contributing author to a number of nutritional and cookery publications including BBC Good Food.

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All health content on bbcgoodfood.com is provided for general information only, and should not be treated as a substitute for the medical advice of your own doctor or any other health care professional. If you have any concerns about your general health, you should contact your local health care provider. See our terms and conditions for more information.

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